Atomoxetine 120mg - Brain and Nervous System Topics
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Qualitative and quantitative composition Each hard capsule atomoxetine atomoxetine hydrochloride equivalent to 10mg, 18mg, atomoxetine 120mg, 25mg, 40mg, 60mg, 80mg or mg of atomoxetine. For the full list of excipients, atomoxetine 120mg, see Section 6. Pharmaceutical form Capsule, hard, atomoxetine 120mg. In adults, the presence atomoxetine symptoms of ADHD that were pre-existing in childhood should be confirmed. Diagnosis cannot 120mg made solely on the presence of 120mg or more symptoms of ADHD.
Additional information for the safe use of this product: A comprehensive treatment programme typically includes psychological, educational and social measures and is aimed at stabilising patients with a 120mg syndrome characterised by symptoms which may include chronic history of short attention span, distractibility, emotional lability, impulsivity, moderate to severe atomoxetine, minor neurological signs and abnormal EEG. Learning may or may not be impaired.
Pharmacological treatment is not indicated in all patients with this syndrome and the decision to use the drug must be based on a very thorough assessment of the severity of the patient's symptoms and impairment in relation 120mg the patient's age and atomoxetine persistence atomoxetine symptoms. Patients who do not achieve a satisfactory clinical response tolerability [e. Dosing of paediatric population up to 70 kg Body Weight: The initial dose should be maintained for a minimum of 7 days prior to upward dose titration according 120mg clinical response and tolerability, atomoxetine 120mg.
The recommended maintenance dose is approximately 1. No additional benefit has been demonstrated atomoxetine doses higher than 1. The safety of single doses over 1. 120mg some cases it might be appropriate to continue treatment into adulthood. Dosing of paediatric population over 70 kg Body Weight: The recommended maintenance dose is 80mg.
Strattera 10mg, 18mg, 25mg, 40mg, 60mg, 80mg or 100mg hard capsules.
No additional benefit has been demonstrated for doses higher atomoxetine 80 mg. The maximum recommended atomoxetine daily dose is mg. The safety of single doses over mg and total daily doses above mg have not been atomoxetine evaluated. The recommended maintenance daily dose is 80mg 120mg mg. Prior to prescribing it is necessary to take an appropriate medical history and conduct a baseline evaluation of a patient's 120mg status, including blood pressure and price for clindamycin 300mg rate see sections 4.
Cardiovascular status should be regularly monitored with blood pressure and 120mg recorded after each adjustment of dose and then at least every 6 months. For paediatric patients the use of a centile chart is recommended. For adults, 120mg reference guidelines for hypertension should be followed.
In the study programme no distinct withdrawal symptoms have been described. In cases of significant adverse effects, atomoxetine 120mg, atomoxetine may be stopped abruptly; otherwise the drug atomoxetine be tapered off over a suitable time period.
Re-evaluation of the need for continued therapy beyond 1 year should be performed, atomoxetine 120mg, particularly when the patient has reached a stable and satisfactory response.
Special Populations Hepatic insufficiency: Atomoxetine may exacerbate hypertension in patients with end-stage renal disease see section 5, atomoxetine 120mg, atomoxetine 120mg.
Patients with this genotype have a several-fold higher exposure to atomoxetine when compared to patients with 120mg functional enzyme, atomoxetine 120mg. Poor metabolisers are therefore at higher risk of adverse events see section 4. For patients with a known poor metaboliser genotype, a lower starting dose and slower 120mg titration of the dose may be considered.
The use of atomoxetine in patients over 65 years atomoxetine age has not been systematically evaluated. Paediatric population under six years of age: Method of administration For oral use.
Strattera can atomoxetine administered with or without food. Atomoxetine atomoxetine not be used in combination with monoamine oxidase inhibitors MAOI, atomoxetine 120mg. 120mg should not be used within a minimum of 2 weeks after discontinuing therapy with MAOI.
Treatment with MAOI should 120mg be initiated within 120mg weeks after discontinuing atomoxetine. Atomoxetine should atomoxetine be used in patients with narrow-angle glaucoma, as in 120mg trials the use atomoxetine atomoxetine was associated with an 120mg incidence of mydriasis, atomoxetine 120mg.
Atomoxetine should not be used in patients with severe cardiovascular or cerebrovascular disorders see section 4. Severe cardiovascular disorders may include severe hypertension, heart failure, arterial occlusive disease, atomoxetine 120mg, angina, 120mg significant congenital heart disease, cardiomyopathies, myocardial infarction, potentially life-threatening arrhythmias and channelopathies disorders finasteride cheapest uk by the dysfunction of ion channels, atomoxetine 120mg.
Atomoxetine cerebrovascular disorders may include cerebral aneurysm or stroke. Atomoxetine should not be used atomoxetine patients with pheochromocytoma atomoxetine a history of pheochromocytoma see section 4.
Strattera 10 mg
atomoxetine Suicide-related behaviour suicide attempts and suicidal ideation has been 120mg in patients treated with atomoxetine. In double-blind clinical trials, suicide-related behaviours were uncommon, but more frequently observed among children and adolescents treated with atomoxetine compared to those treated with placebo, atomoxetine 120mg, where there were no events.
In adult double-blind clinical trials there was no difference in the frequency of suicide-related behaviour between atomoxetine and placebo.
Patients who are being treated for ADHD should be carefully monitored for the appearance or worsening of suicide-related behaviour. Sudden death and pre-existing cardiac abnormalities: Sudden death has been reported in patients with structural cardiac abnormalities who were taking atomoxetine at usual doses. Although some serious structural cardiac abnormalities alone carry an increased risk of sudden death, atomoxetine should only be used with caution in patients with known serious structural cardiac abnormalities and in consultation with a cardiac specialist, atomoxetine 120mg.
Atomoxetine can affect heart rate and blood pressure. Long-term 120mg changes in blood pressure may potentially contribute to clinical consequences such as myocardial hypertrophy. As a result of these findings, patients who are being considered for treatment with atomoxetine should have a careful history and physical exam to assess for the presence of cardiac disease, atomoxetine 120mg, and should receive further specialist cardiac evaluation if initial findings atomoxetine such history or disease.
It is recommended that heart rate and blood pressure be measured and recorded before treatment is started and, during treatment, after each adjustment of dose and then at least every 6 months to detect possible clinically important increases.
Atomoxetine should be used with caution in patients whose underlying medical conditions could be worsened by increases in blood pressure and heart rate, such as patients with hypertension, tachycardia, or cardiovascular or cerebrovascular disease. Patients who develop symptoms such as palpitations, exertional chest pain, unexplained syncope, dyspnoea or other symptoms suggestive of cardiac disease during atomoxetine treatment should undergo a prompt specialist cardiac evaluation.
In addition, atomoxetine should be used with caution in patients with congenital or acquired long QT or a family history of QT prolongation see sections 4. As orthostatic hypotension has also been reported, atomoxetine should be used with caution in any 120mg that may predispose patients to hypotension or conditions associated with abrupt heart rate or blood pressure changes.
Patients with additional risk factors for cerebrovascular conditions such as a history of cardiovascular disease, concomitant medications that elevate blood pressure should be assessed at every visit for neurological signs and symptoms after initiating treatment with atomoxetine.
Very rarely, spontaneous 120mg of liver injury, manifested by elevated hepatic enzymes and bilirubin with jaundice, have been reported. Also very rarely, severe liver injury, including acute liver failure, have 120mg reported. Psychotic or manic symptoms: Treatment-emergent psychotic or manic symptoms, e.
If such symptoms occur, consideration atomoxetine be given to a possible causal role of atomoxetine, and discontinuation of treatment should be considered. Aggressive behaviour, hostility or emotional lability: Hostility predominantly aggression, oppositional behaviour and anger was more frequently observed in clinical trials among children, adolescents and adults treated with STRATTERA compared to those treated with placebo, atomoxetine 120mg.
Patients should be closely monitored for the appearance or worsening of aggressive behaviour, hostility or atomoxetine lability. Although uncommon, allergic reactions, including anaphylactic reactions, rash, atomoxetine 120mg, angioneurotic oedema, and urticaria, have been reported in patients taking atomoxetine.
Seizures are a atomoxetine risk with atomoxetine. Atomoxetine should be introduced with caution in patients with a history of seizure.
Discontinuation of 120mg should be considered in any patient developing a seizure or if there atomoxetine an increase in seizure frequency where no other cause is identified, atomoxetine 120mg.
Growth atomoxetine development should 120mg monitored in children and adolescents during treatment with atomoxetine, atomoxetine 120mg. Clinical data do not suggest a deleterious atomoxetine of atomoxetine on cognition or 120mg maturation; however, atomoxetine 120mg, the amount of available long-term data is limited, atomoxetine 120mg. Therefore, patients requiring long-term therapy should be carefully monitored.
New-onset or worsening of Comorbid Depression, Anxiety and Tics: In a controlled study of paediatric patients with ADHD and comorbid chronic motor tics or Tourette's Disorder, atomoxetine-treated patients did not experience worsening of tics compared 120mg placebo-treated patients.
In a controlled study of adolescent atomoxetine with ADHD and comorbid Major Depressive Disorder, atomoxetine 120mg, atomoxetine-treated patients did not experience worsening of depression compared to placebo-treated patients.
In two controlled studies one in paediatric atomoxetine and one in adult patients of patients with ADHD and comorbid anxiety disorders, atomoxetine-treated patients did not experience worsening of anxiety compared to placebo-treated patients. There have been rare postmarketing reports of anxiety and depression or depressed mood and very rare reports of tics in patients taking atomoxetine see section 4, atomoxetine 120mg. Patients who are being treated for ADHD with atomoxetine should be monitored for atomoxetine appearance or worsening atomoxetine anxiety symptoms, depressed mood and 120mg or tics.
Atomoxetine should not be used with MAOIs see section 4. Atomoxetine patients receiving these drugs, atomoxetine exposure may be 6-to 8-fold atomoxetine and Css max 3 to 4 times higher, because it is metabolised by the CYP2D6 pathway.
Slower titration and final lower dosage of atomoxetine may atomoxetine necessary in patients who are already taking Atomoxetine inhibitor drugs. If a CYP2D6 orlistat 120mg efeitos colaterais is prescribed or discontinued after titration to the appropriate atomoxetine dose has occurred, the clinical response and tolerability should be re-evaluated for that patient to determine if dose adjustment is 120mg.
Caution is advised atomoxetine combining atomoxetine 120mg potent inhibitors of cytochrome P enzymes other than CYP2D6 in 120mg who are poor CYP2D6 metabolisers as the risk of clinically relevant increases in atomoxetine exposure in vivo is unknown.
Salbutamol or other beta2 agonists: Atomoxetine should be administered with caution 120mg patients treated with high dose nebulised or systemically administered salbutamol 120mg other beta2 agonists because cardiovascular effects can be potentiated, atomoxetine 120mg. Contradictory findings regarding this interaction were found.
This effect was most marked after the initial coadministration of salbutamol and atomoxetine but returned towards baseline at the end of 8 hours. Attention should be paid to monitoring heart rate and blood 120mg, and dose adjustments may be justified for either atomoxetine or salbutamol or other beta2 agonists in the atomoxetine of significant increases in heart rate and blood pressure 120mg coadministration of these drugs, atomoxetine 120mg.
There is the potential for an increased risk of QT interval prolongation when atomoxetine is administered with other QT prolonging drugs such as neuroleptics, class IA and III anti-arrhythmics, moxifloxacin, erythromycin, methadone, mefloquine, tricyclic antidepressants, atomoxetine 120mg, lithium, or cisaprideatomoxetine 120mg, drugs that cause electrolyte imbalance such as thiazide diureticsatomoxetine 120mg, and drugs that inhibit CYP2D6, atomoxetine 120mg.
Caution is advised with concomitant use of medicinal drugs which are known to lower the seizure threshold such as tricyclic antidepressants or SSRIs, neuroleptics, phenothiazines or butyrophenone, mefloquine, chloroquine, bupropion or tramadol. In addition, caution is advised when stopping 120mg treatment with benzodiazepines due to 120mg withdrawal atomoxetine. Atomoxetine should be used cautiously with anti-hypertensive drugs.
Attention should be paid to monitoring of blood pressure and review of treatment of atomoxetine or anti-hypertensive drugs may be justified in the case of significant changes of blood pressure. Pressor agents or drugs that increase blood pressure: